Objective To investigate the effect of Captopril on cardiac function and levels of energy-rich phosphates in pressure overload induced left ventricular hypertrophy rats.
Methods Totally, 120 SD rats were randomly divided into three groups: sham operation group (SH) (n=40), coarctation of abdominal aorta group (CAA) (n=40) and Captopril group (CAP) (n=40). Parameters of cardiac function, levels of energy-rich phosphates and morphological changes of the myocardial mitochondria were observed at the 6th and 8th week after this therapy.
Results 1. At 6th week, in CAA group, the cardiac function parameters (LVMI and LVEDP) were increased and±dp/dtmax was decreased, while ATP and ADP were decreased and AMP was increased (p<0.01). These changes were much obvious at 8th week (p<0.01). 2. Compared with that of CAA group, the parameters of heart function and energy-rich phosphates (ATP, ADP, AMP, TAN) in CAP group were improved significantly (p<0.01) at the 6th and 8th week. 3. In CAP group, the parameters of heart function and energy-rich phosphates (ADP, AMP, TAN) were much better at 8th week than that of 6th week. 4. The morphological change of mitochondria was less in CAP group than that in CAA group.
Conclusion Captopril can significantly improve the myocardial energy metabolism in pressure overload rats and can protect the function of myocardial mitochondria.
- Pessure overload
- mocardial energy metabolism
- Energy-rich phosphate
- XinFuKang oral liquid