Article Text

PDF

Basic science: Cardiovascular disease basic research
e0128 Angiotensin-(1-7) inhibits vascular remodelling in rat jugular vein grafts via reduced ERK1/2 and p38 MAPK activity
  1. Wu Jingguo1,
  2. Liang Yanbing1,
  3. Tang Hao1,
  4. Tang Anli2,
  5. Ma Zhongfu1,
  6. Ma Hong1
  1. 1The First Affiliated Hospital Sun Yat-sen University/Department of General Internal Medicine, Guangzhou, China
  2. 2The First Affiliated Hospital Sun Yat-sen University, Department of Cardiology, Guangzhou, China

Abstract

Objects To evaluate the effects of Ang-(1-7) on vascular remodelling in vein grafts.

Methods a model of autologous jugular vein grafts in rats was established. With this model system, rats (n=12 per group) underwent autologous jugular vein graft transplantation (Ang-(1-7) and control groups), or a sham operation (sham group) in which grafting was not performed. Three days after operation, minipumps were installed for continuous infusion of Ang-(1-7) (25 μg/kg/h) or normal saline (control and sham groups) through the jugular vein.

Results 4 weeks, weight, blood pressure and heart rate were not significantly different between groups. Typical venous-graft hyperplasia, vascular remodelling, ERK1/2 activity, p38 MAPK activity and proliferating cell nuclear antigen (PCNA) and a-smooth muscle actin (a-SMA) expression present in the control group were attenuated by continuous Ang-(1-7) infusion. Tissue angiotensin II expression was increased in the Ang-(1-7) and control groups but was not different between the groups.

Conclusion The results of the present study indicate that exogenous Ang-(1-7) interferes with the vascular remodelling of autologous jugular vein grafts and significantly inhibits vein-graft intimal hyperplasia via inhibition of vascular tissue ERK1/2 and p38 MAPK activation. Thus, exogenous Ang-(1-7) improves the outcome of vein grafting via attenuation of vascular remodelling.

  • Ang-(1-7)
  • angiotensin
  • coronary artery bypass graft
  • vascular remodelling

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.