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Basic science: Cardiovascular disease basic research
e0149 Diagnostic implications of TG/HDL-C and PTX-3 in diagnosis of acute coronary syndrome
  1. Zhang Li,
  2. Liu Qiming,
  3. Zhou Shenghua,
  4. Qin Haibin,
  5. Zhao Shuiping
  1. The Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, China

Abstract

Objective To investigate the value of serum pentraxin-3 (PTX-3) together with triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) as a predictor risk factor for future acute coronary syndrome (ACS).

Methods Collected and analysed 171 cases of Department of Cardiology of the Second Xiangya Hospital of Central South University in July 2008∼December 2009 for elective coronary angiography patients, according to the situation on admission and coronary angiography, patients were divided into three groups: normal control subjects, stable angina pectoris and acute coronary syndrome group, all patients admitted to hospital were extracted fasting venous blood for measuring PTX-3 and lipids (TG, HDL-C) level in the next morning, and Statistically analysed, p<0.05 was considered statistically significant.

Results The serum PTX-3 levels and the ratio of TG and HDL-C in patients with acute coronary syndrome (6.39±3.01 ng/ml; 2.38±2.00) were significantly increased than those in stable angina pectoris (3.87±2.05 ng/ml; 1.70±1.01) and normal control subjects (2.90±1.94 ng/ml, 0.95±0.35), p<0.05.

Conclusions Increased serum PTX-3 and ratio of TG and HDL-C in patients are closely related with acute coronary syndrome, both increase accuracy of early diagnosis of acute coronary syndrome.

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