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Basic science: Cardiovascular disease basic research
e0162 The relationship between the G (+252)A polymorphism of β2-adrenergic receptor gene and essential hypertension in Kazaks of Xinjiang
  1. Liu Kejian,
  2. Li Nanfang,
  3. Zhou Ling,
  4. Yao Xiaoguang,
  5. Li Tao,
  6. Yan Zhitao
  1. Department of Echocardiography, Center of the Medical Ultrasound, The First Affiliated Hospital of Xinjiang Medical University, Urmuqi, China


Introduction Hypertension is a major risk factor for coronary artery disease, stroke, and renal disease. Recent research suggest genetic polymorphisms of β2-adrenergic receptor gene (ADRB2) have already been associated with obesity, diabetes mellitus, and essential hypertension, with conflicting results. Kazakans of the pasturing area in Xinjiang, China, have higher prevalence of hypertension and mean blood pressure than other populations of Xinjiang. But up to now no study in this population. To investigate the relationship between the G (+252)A polymarphism of ADRB2 gene and essential hypertension in Kazaks of Xinjiang.

Method A total of 276 patients with confirmed hypertensives and 157 healthy control were genotyped for the G (+252)A by PCR restriction fragment length polymorphism (PCR-RFLP) analysis.

Result Compared with control group, there was no significant difference in the distribution of genotypes and allele frequency of G (+252) A polymorphisms in EH group (p>0.05). In addition, age, body mass index, systolic blood pressure and diastolic blood pressure had no significant difference in the groups classified according to genotypes (p>0.05).

Conclusion G (+252)A polymorphism of β2-AR gene was not related with essential hypertension in Kazaks of XinJiang.

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