Objective To investigate the acute proarrhythmic effects of low concentration BPA on adult rat and to demonstrate the electrophysiologic mechanisms.
Methods and results Acute exposure to BPA increased the contractility of cardiac myocytes from female rat heart with inverted U-shaped dose-response curve, these effects were female specific. After-contraction or after-transient rate of female rat cardiac myocytes increased in BPA group, and increased much more by exposure to the mixture of BPA and 10−9 M E2. Increasing BPA or E2 from 10−9 M to 2X 10−9 M did not increase the effects induced responses. Although BPA combined with E2 did not induce the premature ventricular beats of ex vivo heart, under the acute adrenergic challenge, they significantly enhanced the frequency of premature ventricular beats.
Conclusions BPA promotes arrhythmogenesis in female rat heart by induced DADs, and effects of BPA and E2 are synergistic instead of additive.
- Bisphenol A
- delayed after depolarisation
- female specific