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Basic science: Experiment research
e0184 The protection effects of trimetazidine on rats myocardial infraction
  1. Yanting Luo1,
  2. Jinlai Liu1,
  3. Fei Chen2,
  4. Wen Tan2
  1. 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  2. 2Key-Pharma Biomedical Company, Dongguan, P. R. China

Abstract

Objective To observe the myocardial protection effects of trimetazidine on Sprague-Dawley (SD) rats with myocardial infarctions (MI).

Methods 90 SD rats were randomly assigned to normal control group (NL, n=30), Trimetazidine group (T, n=30) and sham-operated group (S, n=30). The MI model was set up in SD rats by permanent ligation of the left anterior descending coronary artery. In S group suture was through the left anterior descending coronary artery without ligation. Before and after MI, in NL group/S group and T group normal saline and Trimetazidine (0.3 mg/kg) were separately given by gavage. The changes of serum cTnI were observed at 8, 24, 48 h after MI. The changes of serum cTnI in S group was only observed at 24th hour after operations. In 1 week, 2 weeks and 4 weeks after treatment, the areas of myocardial infarction were analysed, and isovolumic systolic left ventricular maximum rate of pressure rise (+dp/dtmax) and isovolumic diastolic left ventricular maximum rate of pressure drop (−dp/dtmin) were measured to evaluate the myocardial protection effects of STV-1Na. The groups were compared with one-way analysis of variance (ANOVA) test. A value of p 0.05 between NL group and T group. But the serum cTnI level at 24 h after MI decreased in T group (22.7±5.3 ng/ml, p<0.05) compared with NL group (42.3±5.4 ng/ml). The serum cTnI level at 24 h in NL group and T group was significantly increased compared with S group (1.59±1.42 ng/ml) (p<0.01). Trimetazidine (0.248±0.021, p<0.01) decreased significantly the myocardial infarction area compared with NL group (0.362±0.027). The infarction areas in NL group (0.362±0.027) and T group (0.248±0.021) increased significantly compared with S group (0.072±0.1445) (p<0.01). In 1 week after MI, the +dp/dtmax in T group (7535±265) was not significantly different (p>0.05) compared with NL group (6702±329), and the -dp/dtmin in T group (−5511±400) was no significant difference (p>0.05) compared with NL group (−5400±339). In 2 weeks after MI, the +dp/dtmax in T group (8101±313) increased significantly compared with NL group (5868±412) (p<0.01), and the −dp/dtmin in T group (−6514±493) decreased significantly compared with NL group (−4750±463) (p<0.05). In 4 weeks after MI, in T group (7629±374) the +dp/dt max increased significantly compared with NL group (5876±200) (p<0.01,), and the −dp/dtmin in T group (−5883±436) decreased significantly compared with NL group (−4546±279) (p<0.05). The -dp/dt max in T group and NL group were significantly decreased (p<0.05) compared with S group in 1 week, 2 weeks and 4 weeks after the operation. The+dp/dtmin in T group and NL group were increased (p<0.05) compared to S group in 1 week, 2 weeks and 4 weeks after the operation.

Conclusions Trimetazidine has myocardial protection effects on myocardial infarction and improves myocardial systolic and diastolic function in SD rats with acute myocardial infarction.

  • Trimetazidine
  • myocardial infarction
  • cardiac function
  • sprague-dawley rat

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