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Basic science: Cardiovascular disease basic research
e0019 Study on the changes of matrix metalloproteinase-9 and high sensitive C-reactive protein in patients with carotid intima-media thickness
  1. Yun-Kai Wang,
  2. Yun-Fen Wei,
  3. Meng-Hong Wang,
  4. Ze-Qi Zheng,
  5. Lin-Li Wang,
  6. Yin-Sheng Wu
  1. Department of Cardiology, the First Affiliated Hospital of Nan Chang University

Abstract

Objective To investigate the relationship between matrix metalloproteinase-9, high sensitive C-reactive protein and carotid intima-media thickness.

Methods 180 patients were selected. High-resolution ultrasound was used to scan carotid, brachial arteries of all patients in order to check and measure carotid intima-media thickness (CIMT), plaques of carotid arteries and diameter of brachial arteries at rest. Patients were divided into four groups: the normal carotid intima group, the difficuse proliferative carotid intima group, the stable plaque group and the unstable plaque group. Serum levels of MMP-9, hsCRP were determined with immunological method. The relationship between the results measured by ultrasound instrument and the concentrations of MMP-9, and hsCRP was analysed.

Results The serum levels of MMP-9 and hsCRP in the proliferative carotid intima group were higher than in the normal carotid intima group (p<0.01). The serum levels of MMP-9 and hsCRP in the unstable plaque group and in the stable plaque group were higher than in difficuse proliferative carotid intima group (p<0.05). The serum levels MMP-9 and hsCRP in the unstable plaque group were higher than in the stable plaque group (p<0.05).

Conclusion The increased concentrations of MMP-9 and hsCRP were closely correlated with the increment of carotid intima-media thickness, the unsteady of plaque.

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