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Basic science: Experiment research
e0222 Effects and function mechanism of hydrogen sulfide on myocardial ischaemia reperfusion arrhythmia in rats
  1. Chen Xiehui1,
  2. Li Peng1,
  3. Huang Xiaoping1,
  4. Wang Dongming2,
  5. Chen Songming2,
  6. Yang Zeming1,
  7. Chen Zhifan1,
  8. Xu Wenmin1,
  9. Chen Liping1
  1. 1The 2nd People's Hospital of Futian District, Shenzhen, Guangdong, China
  2. 2The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China

Abstract

Objective To explore the Effects and Function Mechanism of hydrogen sulfide on Myocardial Ischaemia reperfusion Arrhythmia in Rats.

Methods We used sodium hydrosulfide (NaHS) as the donor of H2S, SD rats were randomly divided into sham group, Myocardial Ischaemia reperfusion group (IR group), IR+NaHS group, and IR+NaHS+glibenclamide group. We monitor the Haemodynamics of rats, including heart rate, arterial pressure, left ventricular pressure et al. We also observe the rate of ventrical arrhythmia in each group.

Result H2S can significantly reduces rats’ heart rate, arterial pressure and left ventricular pressure. It also reduces the rate of ventrical arrhythmia in Myocardial Ischaemia reperfusion Rats. The KATP Channel Blocker glibenclamide can weaken the H2S’ Antiarrhythmic effects (p<0.01).

Conclusions H2S can reduces the rate of ventrical arrhythmia in Myocardial Ischaemia reperfusion Rats. The Function Mechanism may be associated with the KATP signal transduction pathway in cells.

  • Hydrogen sulfide
  • myocardial ischaemia reperfusion
  • arrhythmia
  • ATP sensitive potassium channel

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