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Epidemiology and preventive medicine: Epidemiology of cardiovascular disease
e0253 Epidemiological characteristics and reference ranges of brachialankle pulse wave velocity in China
  1. Wu Lezhou1,
  2. Zheng Liqiang1,
  3. Li Jue1,
  4. Hu Dayi1,
  5. Hasimu Buaijiaer2,
  6. Yuan Hong3,
  7. Yang Jingang4,
  8. Sun Yingxian5
  1. 1Heart Lung and Blood Vessel Center Tongji University Shanghai, China
  2. 2Heart Centre The First Affiliation Hospital of Xinjiang Medical University Urumqi, China
  3. 3Department of Cardiology Xiangya Third Hospital of South Central University Changsha, China
  4. 4Cardiovascular Center Fuwai Hospital of Chinese Academy of Medical Science Beijing, China
  5. 5Department of Cardiology The First Hospital of China Medical University Shenyang, China

Abstract

Introduction The present study aimed to examine the epidemiological distribution and to develop the gender- and age-specific reference ranges of brachial-ankle pulse wave velocity (baPWV) in China.

Materials and Methods A total of 21, 094 subjects (15–92 years) were recruited in a cross-sectional study which was conducted from June 2007 to June 2008 in China. The population was divided into 3 clinical subgroups in our study: (1) Subgroup 1: subjects with atherosclerotic cardiovascular diseases; (2) Subgroup 2: subjects with atherosclerotic risk factors; (3) Subgroup 3: “healthy subjects” without any atherosclerotic cardiovascular diseases and atherosclerotic risk factors.

Results The average baPWV among subgroup 1 to 3 were 1,724.3±429.1, 1,603.5±358.8, and 1,389.9±288.4 cm/s, respectively. BaPWV as a variable was not fit of normal distribution in both genders. There was no significant difference between male and female for baPWV in subgroup 1 (p>0.05). While baPWV was higher in females than males in subgroup 2, it was lower in females than in males in subgroup 3 (all p<0.05). BaPWV was dramatically increased with age in both genders (all p for trend<0.05). The gender- and age-specified reference ranges for baPWV by percentiles in healthy subjects were presented in the study. The receiver operator characteristic curve demonstrated that a baPWV of 1,450 cm/s was useful to discriminate either cardiovascular diseases or atherosclerotic risk factors (sensitivity 62.1%, specificity 69.5%).

Conclusions We should combine the reference ranges and the cutoff value of baPWV to screen and prevent atherosclerotic cardiovascular diseases in clinical practices.

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