Aim A low ankle-to-brachial index (ABI) is a strong correlate of cardiovascular disease and subsequent mortality. The relationship between ABI and alcohol consumption remains unclear.
Methods and Results Data are from the Cardiovascular Risk Survey (CRS), a multi-ethnical community-based study of 14 593 Chinese people (5749 Han, 4747 Uighur, and 4097 Hazakh) aged 35 years and over at baseline in June 2007 to March 2010. The relationship between alcohol intake and ABI were determined by use of analysis of covariance and multivariable regressions. In men, a linear correlation between alcohol consumption and ABI was found by one-factor analysis of variance (p<0.001); After adjusted for the age, sex, ethnicity, blood pressure, body mass index, smoking, GLU, total cholesterol, HDL, and LDL, the difference remains significant (p=0.007). The multivariate-adjusted OR for peripheral artery disease was significantly higher in men who consumed >60.0 g/d (OR=1.997, 95% CI 1.500 to 2.989) and was significantly lower in men who consumed 20.0–40.0 g/d compared with never drinking, respectively (p=0.01, p=0.027, respectively, data not shown). Neither ABI nor PAD was correlated with alcohol intake in women.
Conclusions Our results indicated that in Chinese men, moderate drinking is a protective factor but heavier drinking is a risk factor for peripheral arteriosclerosis.