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Epidemiology and preventive medicine: Epidemiology of cardiovascular disease
e0267 Prediction of the newly-identified carotid plaque with blood lipid levels in Chinese elderly population
  1. Wang Wei,
  2. Huo Yong,
  3. Zhao Dong,
  4. Liu Jing,
  5. Sun Jiayi,
  6. Wang Miao,
  7. Wu Yangfeng
  1. Department of Epidemiology, Capital Medical University Affiliated Anzhen Hospital, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Beijing China

Abstract

Objective To provide the changing prevalence of carotid plaque in a Chinese elderly population from 2002 to 2007 and accordingly evaluate the predictive effect of baseline lipid levels of interest on the newly-identified carotid plaque.

Methods All study subjects were recruited from two cohorts, viz. the People's Republic of China/United States of America Collaborative Study (USA-PRC Study) and the Chinese Multi-provincial Cohort Study (CMCS). The baseline examination was taken in 2002 including CVD risk factors and B-mode ultrasound of carotid artery and the second examination was carried out in 2007. The carotid plaque was measured in a total of 2000 subjects aged 47–79 years (mean 63 year).

Results 1. During these 5 years, the prevalence of carotid plaque increased from 30.3% to 62.2% and from 21.5% to 51.5% for men and women, respectively. The newly-identified carotid plaque incidence reached 41.8% for men and 34.1% for women. 2. With the increase of baseline total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG, except for men), non-high-density lipoprotein cholesterol (non-HDL-C), and total to high-density cholesterol ratio (TC/HDL-C) levels, the artery plaque incidence significantly increased in both sexes (p<0.05). 3. Cross-stratification analysis of LDL-C, TG and HDL-C for carotid plaque incidence indicated the existence of conjoint effects between LDL-C and HDL-C, LDL and TG, as well as between TG and HDL-C, on the elevated carotid plaque. For example, at the normal levels of LDL-C and HDL-C, the plaque incidence was 23.3%, whereas the abnormal levels of these two lipids yielded an exceedingly high incidence of 49.0%. 4. In multifactorial analysis, higher LDL-C, non-HDL-C and TC/HDL-C was recognised as an independent factors of carotid plaque incidence (RR=1.44, 95% CI 1.07 to 1.94; RR=1.45, 95% CI 1.08 to 1.96; RR=1.59, 95% CI 1.14 to 2.23 in men; RR=1.47, 95% CI 1.13 to 1.92; RR=1.35, 95% CI 1.04 to 1.75; RR=1.64, 95% CI 1.20 to 2.23 in women).

Conclusions The prevalence of carotid plaque increased rapidly in a Chinese elderly population. Elevated LDL-C, non-HDL-C and TC/HDL-C levels serve as predictor of carotid plaque incidence.

  • Ultrasonography
  • carotid arteries
  • plaque
  • lipid
  • epidemiology

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