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Basic science: Cardiovascular disease basic research
e0026 Association between the M235T, T174M polymorphism of the angiotensinogen gene and left ventricular hypertrophy in essential hypertension in Kazakans
  1. Zuo Junli1,
  2. Li Nanfang2,
  3. Zhang Delian3,
  4. Zhou Ling4,
  5. Li Tao2
  1. 1Hypertension Unit of The People's Hospital of Xinjiang Uygur Autonomous Region, The Institute of Hypertension of Xinjiang, The Center of Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region
  2. 2Hypertension Unit of The People's Hospital of Xinjiang Uygur Autonomous Region
  3. 3The Institute of Hypertension of Xinjiang
  4. 4The Center of Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region
  1. Correspondence to Li Nanfang; lnanfang{at}yahoo.com.cn

Abstract

Objective To investigate whether the M235T, T174M polymorphisms of the angiotensinogen gene were associated with left ventricular hypertrophy (LVH) in Xinjiang Kazakans with essential hypertension.

Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with essential hypertension and non-left ventricular hypertrophy. Left ventricular hypertrophy was evaluated by the electrocardiography voltage criteria and the Romhilt-Estespoint-score system. The AGT gene M235T, T174M polymorphisms were amplified by PCR and analysed by RFLP.

Results (1) The genotype distributions of the M235T and T174M in both groups were in agreement with Hardy–Weinberg equilibrium. (2) The frequencies of the AGT genotypes and alleles were not significantly different between LVH and NLVH with hypertension. (3) When analysing the frequencies of genotypes and alleles of M235T according to gender (p>0.05), no significant differences were found between LVH and NLVH. However, we found a significant difference in frequencies of genotypes and alleles of T174M in NLVH group according to gender.

Conclusion There are no associations between M235T genotype and T174M genotype with the presence of LVH in this study.

  • Angiotensinogen gene
  • polymorphism
  • essential hypertension
  • left ventricular hypertrophy

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