Background and Objective Although extensive research has shown the association of decreased renal function with early arteriosclerosis in patients with chronic kidney disease, it's still controversy whether decreased glomerular filtration rate (GFR) and menopause have independent relationship with arterial stiffness in general women residents with normal renal function. The aim of this study was to identify how decreased GFR or menopause contributes to central and peripheral arterial stiffness.
Methods In this cross-sectional study, we randomly recruited 1,131 women residents (mean age: 56.59±14.16 years) with normal GFR levels estimated by the abbreviated Modification of Diet in Renal Disease equation (defined as eGFR ≥60 ml/min/1.73 m2) from three large communities in Beijing. Arterial stiffness was assessed by measuring carotid-femoral PWV (PWVcf), carotid-radial PWV (PWVcr) and augmentation index (AIx) with validated automatic devices. Menopause status was defined by the cut-off age of 50, the median menopause age of Chinese women.
Results Subjects from the lowest eGFR tertile group had the highest PWVcf and AIx, while the values of PWVcr were comparable. Meanwhile, eGFR was inversely correlated with PWVcf and AIx but not with PWVcr. Multiple stepwise regression demonstrated a significant relationship between eGFR and PWVcf, independent of the conventional atherosclerotic risk factors. This association was not significant between eGFR values and PWVcr or AIx. Lower eGFR accompanied by higher PWVcf and AIx was evident in the post-menopause group while the PWVcr values were comparable. Post-menopause was an independent predictor for PWVcf and AIx, but not for PWVcr.
Conclusions In general Chinese women with normal renal function, decreased eGFR seems to affect the core arteries other than the peripheral ones. Post-menopause might play part role in arterial stiffness.