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Epidemiology and preventive medicine: Lipid research
e0302 Effects of xuezhikang on blood lipids and the levels of plasma endothelins, thromboxane B2, 6-keto-PGF—1a in Patients with primary hyperlipidaemia
  1. Wei Liao,
  2. Yong-ling Liao
  1. Department of Cardiology, The Affiliated Hospital of Gannan Medical College

Abstract

Objective To observe the effects of Xuezhikang on blood lipids and the levels of plasma endothelins, thromboxane B2, 6-keto-PGFla in patients with primary hyperlipidaemia.

Methods 120 patients with primary hyperlipidaemia were enrolled in this study, 82 males and 38 females, age 36–74 years old, average ages (55±9) years old. 12 weeks after taking Xuezhikang, the clinical effect and the effect on the level of plasma endothelins, thromboxane B2, 6-Keto-PGFla were compared before and after the treatment, and the relation between blood lipids and ratio of plasma endothelins, thromboxane B2 to 6- Keto-PGFla were analysed.

Results 12 weeks after treatment, the level of TG, cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and apoB100 decreased sharply (p<0.05–0.001); the level of serum high density lipoprotein cholesterol (HDL-C) elevated (p<0.05); ratio of plasma endothelins decreased sharply (p<0.001); rate value of thromboxane B2 to 6-Keto-PGFla before treatment was higher than health people but lower after treatment (p<0.01). There were positive correlations between the decreased TC. TG, LDL-C and decreased ET-1, the ratio TXB2/6-keto-PGFla (r=0.832–0.963, p<0.01–0.001). The same positive correlation was found between the decreased ET-1 and the ratio of TXB2/6-keto-PGF1a (r=0.987, p<0.001).

Conclusions Plasma endothelins level and ratio of thromboxane B2 to 6-Keto- PGFla increased in the patients with primary hyperlipidaemia. Xuezhikang not only effectively adjusted blood lipids level but also reduced plasma endothelins level and ratio of thromboxane B2 to 6-Keto- PGFla.

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