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Epidemiology and preventive medicine: Metabolic syndrome and diabetes
e0307 Clinical research of noninvasive cardiac haemodynamics in middle-aged and old with type 2 diabetes mellitus
  1. Fei Yu,
  2. Bao-Ying Li,
  3. Shan-Shan Shi,
  4. Qian Wang,
  5. Zhi-Mian Zhang,
  6. Hai-Qing Gao
  1. Qilu Hospital of Shandong University, Jinan, China

Abstract

Objective To explore the characteristics of cardiac haemodynamics in middle-aged and old with type 2 diabetes mellitus, and to discussion the sensitive indicators to determine the early heart disease by Lifegard ICG Haemodynamic Monitor.

Methods 218 individuals (mean age 62.11±10.71 years) were recruited in this study. Cardiac outpute (CO), cardiac index (CI), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), stroke volume (SV), stroke index (SI), thoracic fluid content (TFC), acceleration index (ACI), left cardiac works index (LCWI), pre-ejection period (PEP), left ventricular ejection time (LVET), velocity index (VI), contraction time ratio (STR), heart rate (HR) and mean arterial pressure (MAP) were measured using Lifegard ICG Haemodynamic Monitor.

Results (1) Compared with the healthy controls, there was significant difference in the waist-hip ratio (WHR), fasting blood glucose (FPG), total cholesterol (TC), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), acceleration index (ACI), velocity index (VI), pre-ejection period (PEP), contraction time ratio (STR) of patients with type 2 diabetes mellitus (p<0.05 or p<0.01). (2) Compared with the healthy controls, there was significant difference in the fasting blood glucose (FPG), acceleration index (ACI), velocity index (VI) of patients with pre-diabetes (p<0.05 or p<0.01). (3) Correlation analysis: ACI related negatively with body mass index, waist-hip ratio, fasting blood glucose, systolic blood pressure, diastolic blood pressure, mean artery pressure and heart rate; PEP related positively with body mass index; VI related negatively with body mass index, waist-hip ratio, fasting blood glucose, systolic blood pressure, diastolic blood pressure, mean artery pressure and heart rate; STR related positively with body mass index and waist-hip ratio.

Conclusion Cardiac haemodynamics impaired to varying degrees in diabetes mellitus and pre-diabetes, the body mass index is the common risk factor on the reduction of these indicators. ACI and VI measurements are noninvasive and sensitive indicators of evaluating abnormalities of cardiac haemodynamics in diabetes mellitus.

  • Diabetes
  • noninvasive cardiac haemodynamics

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