Objective To explore the level of plasma visfatin in patients with coronary artery disease (CAD) and different BMI, and evaluate the relationship between plasma visfatin and coronary lesion severity in obese patients with CAD.
Methods 59 causes were undergone coronary angiography and divided into three sub-groups: normal weight (13 causes) (BMI<24 kg/m2), over weight (31 causes) (24≤BMI<28 kg/m2) and obese groups (15 causes) (BMI≥28 kg/m2). The levels of plasma visfatin of CAD group and control group were measured and compared. The correlation between plasma visfatin and coronary lesion severity score with different BMI was analysed.
Result The plasma visfatin level was higher in the CAD group (547.21±94.18 ng/ml) comparing with the control group (470.86±87.99 ng/ml). In obese patients with CAD the plasma visfatin level (586.62±96.77 ng/ml) increased more significantly and it was positively correlated with Gensini score (p<0.05).
Conclusion The level of plasma visfatin is closely correlated with coronary lesion severity in obese patients with CAD. It might be used as a new clinical marker to predict the severity of coronary lesion in obese patients with CAD.
- coronary artery disease
- Gensini score