Objective We investigated clinical correlates of in-hospital mortality and comorbidity of patients demonstrating heart failure progression in a large population.
Methods We included 6,949 patients with demonstrating heart failure who were hospitalised from the period of January 1, 1993, to December 31, 2007, at Chinese PLA General Hospital in Beijing. Hospital mortality and comorbidities were examined for the patients primarily admitted for decompensated HF.
Results The 30-day in-hospital mortality was 5.4% in patients. Cox regression multivariate analysis showed that a history of cor pulmonale, stroke, renal failure, cirrhosis of liver-myocardial infarction, pneumonia, gastrointestinal bleeding and multiple organ dysfunction syndromes and age older than 65 years were the only independent predictors of in-hospital mortality. Using the regression coefficient as a benchmark, we calculated a convenient score. Nearly 23% of the patients with the score >6 died compared with only 1.2% of the patients with the score of 0.
Conclusion Medical comorbidity at admission or age older than 65 years is an independent risk factor for 30-day mortality in patients with heart failure. The study illustrates that medical comorbidities at admission have proved to be a major prognostic marker for immediate poor outcome in the patients with heart failure. The score may help to identify patients who are more likely to have a risk of in-hospital mortality within 30-days.