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  1. Renicus S Hermanides,
  2. Arnoud W J van 't Hof
  1. Isala Klinieken, Department of Cardiology, Zwolle, The Netherlands
  1. Correspondence to Arnoud W J van 't Hof, Isala klinieken, Department of Cardiology, Groot Wezenland 20, Zwolle 8011 JW, The Netherlands; v.r.c.derks{at}isala.nl

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We thank Dr Lin and colleagues1 for their comments regarding the outcomes of 30-day major adverse cardiac events (MACE) in the pre-defined subgroup analysis of the Ongoing Tirofiban In Myocardial infarction Evaluation 2 trial (On-TIME 2).2 There are different aspects of their comments that can be addressed.

First, although prehospital use of high dose tirofiban reduces the use of bail-out study medication, and this need for bail-out study medication was associated with a less …

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