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Polymorphisms of matrix metalloproteinases in myocardial infarction: a meta-analysis
  1. Junhong Wang1,
  2. Di Xu1,
  3. Xin Wu2,
  4. Chuanwei Zhou1,
  5. Hui Wang1,3,
  6. Yan Guo1,
  7. Kejiang Cao1
  1. 1Department of Gerontology, the first affiliated hospital of Nanjing Medical University, Nanjing, China
  2. 2Department of Clinical Laboratory Medicine, Benq Medical Center, Nanjing Medical University, Nanjing, China
  3. 3Department of Cardiology, The Shengze Hospital of Jiangsu Province, SuZhou, China
  1. Correspondence to Professor Guo Yan, Department of Gerontology, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, PRC, China; guoyan51{at}hotmail.com

Abstract

Context The literature provides no clear answer as to whether matrix metalloproteinases (MMPs) polymorphisms increases risk of myocardial infarction (MI).

Objective Our purpose was to help clarify the inconsistent findings of MMPs polymorphisms and MI susceptibility and identify which MMP polymorphism might play an active role in the occurrence of MI.

Data Sources Articles were identified by a Medline search and citation tracking.

Study Selection Eligible articles were case–control studies of MMPs polymorphisms and MI which met our prespecified criteria.

Data extraction Data were independently extracted by two authors according to a predefined protocol. Incongruities were settled by consensus decision.

Results and Conclusions 18 potentially eligible articles were identified. In a combined analysis, the 5A allele of the MMP-3 5A/6A polymorphism was associated with MI (OR 1.21, 95% CI 1.01 to 1.46, p=0.04), suggesting its role in plaque rupture. In the subgroup analysis by ethnicity, significantly increased risk was found among East Asians (OR 1.39, 95% CI 1.01 to 1.91, p=0.04), whereas no significant association was detected in Caucasian populations. In addition, there were significant associations of the MMP-9 -1562CT polymorphism with MI (OR 1.14, 95% CI 1.02 to 1.27, p=0.02), whereas the heterogeneity of the studies showed no significance (I2=13.7%, p=0.32). This meta-analysis demonstrated that the MMP-3 5A/6A and MMP-9 -1562 CT polymorphisms are risk factors associated with increased MI susceptibility, but these associations vary in different ethnic populations.

  • MMPs
  • myocardial infarction
  • polymorphisms
  • cardiac remodelling
  • inflammation
  • coronary artery disease
  • cytokines
  • cardiac function
  • genetics

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Footnotes

  • Funding This work was supported by the National Natural Science Foundation of China (NSFC 30900602 to Dr Wang Junhong).

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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