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Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation
  1. Michifumi Tokuda1,
  2. Teiichi Yamane1,
  3. Seiichiro Matsuo1,
  4. Keiichi Ito1,
  5. Ryohsuke Narui1,
  6. Mika Hioki1,
  7. Shin-ichi Tanigawa1,
  8. Tokiko Nakane1,
  9. Seigo Yamashita1,
  10. Keiichi Inada1,
  11. Kenri Shibayama1,
  12. Satoru Miyanaga1,
  13. Hiroshi Yoshida1,
  14. Hidekazu Miyazaki1,
  15. Taro Date1,
  16. Takashi Yokoo2,
  17. Michihiro Yoshimura1
  1. 1Department of Cardiology, Jikei Unversity School of Medicine, Minato-ku, Tokyo, Japan
  2. 2Department of Kidney and Hypertension, Jikei Unversity School of Medicine, Minato-ku, Tokyo, Japan
  1. Correspondence to Dr Teiichi Yamane, Department of Cardiology, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan; yamanet1{at}aol.com

Abstract

Background Although several clinical variables are associated with the recurrence of atrial fibrillation (AF) following catheter ablation, the influence of renal function remains to be determined.

Objective To evaluate the association of renal function with the outcome of the paroxysmal AF ablation.

Methods 224 patients underwent catheter ablation for paroxysmal AF. The relationship between the pre-procedural clinical valuables and ablation outcomes was evaluated.

Results Over the course of 37.4±24.4 months of follow-up of catheter ablation procedures for AF (mean number of procedures 1.33±0.45), 91.1% of patients (204/224) became free from AF without antiarrhythmic drugs. The estimated glomerular filtration rate (eGFR) was lower in patients with recurrent AF than in those without recurrence (66.6±17.5 vs 78.4±16.8 ml/min/1.73 m2, p=0.003). AF recurred more frequently in patients with low eGFR (<60 ml/min/1.73 m2) than in those with high eGFR (>60 ml/min/1.73 m2; 24.3% vs 6.7%, p=0.006). Among the various clinical factors, low eGFR (p=0.02) and left atrium (LA) dilatation (p=0.002) independently predicted the clinical outcome of ablation in patients with paroxysmal AF.

Conclusion Low eGFR and LA dilatation independently influence the outcome of catheter ablation for paroxysmal AF.

  • Atrial fibrillation
  • catheter ablation
  • recurrence
  • renal function
  • radiofrequency ablation (RFA)

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the ethics committee of Jikei University School of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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