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To the Editor We read with great interest the article by Suárez-Barrientos et al1 regarding circadian oscillations on infarct size. Although the article is both exhaustive and clinically relevant, we felt that the authors failed in the recognition of the potential value of melatonin in the association between cardiovascular events and circadian variation.
Synchrony between external and internal circadian rhythms and harmony among molecular fluctuations within cells are essential for normal organ biology. Circadian clocks exist within multiple …