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  1. Paolo Alboni
  1. Correspondence to Dr Paolo Alboni, Division of Cardiology, Ospedale Civile, Cento (FE), Italy; p.alboni{at}ausl.fe.it

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The Authors' reply We thank Drs Kirchhof, Crijns and van Gelder1 for their interest in our paper2 referring to pill-in-the-pocket treatment of recent-onset atrial fibrillation (AF). The study was interrupted on the recommendation of the data- and safety-monitoring committee because the results suggested that the intravenous administration of flecainide or propafenone does not predict the occurrence of adverse effects after a loading oral dose of these drugs. A 5% incidence of major side effects during the first out-of-hospital treatment was regarded as high, considering that such patients have haemodynamically well-tolerated episodes of AF. All the …

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    Charles J H J Kirchhof H J G M Crijns I C van Gelder
  • PostScript
    BMJ Publishing Group Ltd and British Cardiovascular Society