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  1. Madeleine Bruins Slot1,
  2. Frans Rutten1,
  3. Hans Reitsma2,
  4. Geert van der Heijden1,
  5. Arno W Hoes1
  1. 1University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands
  2. 2Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, AMC, the Netherlands
  1. Correspondence to Madeleine Bruins Slot, University Medical Center Utrecht, Julius Center, PO Box 85500, 3508 GA Utrecht, the Netherlands; m.h.e.bruinsslot{at}umcutrecht.nl

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The Authors' reply We thank Shand et al for their comments1 on our systematic review and meta-analysis.2

We agree with Shand et al that when assessing the diagnostic value of heart-type fatty acid-binding protein (H-FABP), it should be measured in the relevant time interval (ie, 1–24 h after the onset of complaints). Because H-FABP is a sensitive early marker of myocardial necrosis, it can have major advantages over troponin within the first 6 h after symptom onset, when troponin can still be …

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