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Cardiovascular highlights from non-cardiology journals
  1. Alistair C Lindsay, Editor

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General cardiology

Renal function markers and cardiovascular risk

Although a low Glomerular Filtration Rate and albuminuria have previously been independently linked with an increased risk of cardiovascular disease, it has not yet been established whether either measurement adds additional prognostic information beyond that of traditional cardiovascular risk factors.

Using data from the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial and Telmisartan Randomised Assessment Study in Angiotensin-Converting-Enzyme-Inhibitor Intolerant Subjects with Cardiovascular Disease studies, Clase and colleagues studied 27 620 patients over the age of 55 years. All patients had documented cardiovascular disease and the mean length of follow-up was 4.6 years.

The authors confirmed that lower eGFRs and higher urinary albumin-creatinine ratios were associated with the primary cardiovascular composite outcome, however they also noted that adding these measurements to traditional cardiovascular risk factors led to no meaningful decrease in the number of patients categorised as intermediate risk (31% without vs 32% with). However, the authors did note that these measurements greatly improved risk …

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