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Metabolic syndrome and diabetes
The effect of metabolic syndrome on carotid artery intima-media thickness in patients with essential hypertension
  1. Wan Zheng1,
  2. Yao Wei1,
  3. Sun Yuemin1,
  4. Li Yongle1,
  5. Lu Wenli2,
  6. Yu Xuefang1,
  7. Wang Yuan2,
  8. Wang Jianhua2
  1. 1Tianjin Medical University General Hospital, Tianjin, China
  2. 2Tianjin Medical University, Tianjin, China

Abstract

Objective To evaluate the influence of the metabolic syndrome (MS) on artery intima-media thickness (IMT) and/or plaque in patients with essential hypertension (EH).

Methods A total of 1505 EH patients were chosen, including 659 male patients and 846 female patients, with age from 20 to 90 years old. These patients were divided into MS group (EH with MS) and non-MS group (EH without MS), MS group was then divided into glucose abnormal subgroup, fat abnormal subgroup and glucose and fat both abnormal subgroup. Carotid IMT and plaque were detected and measured by B-ultrasound.

Results The age, abdominal circumference, body mass index (BMI), fasting blood glucose (FBG), total cholesterol (TC), total triglycerides (TG), low density lipoprotein cholesterol (LDL-C), uric acid (UA) and hypersensitive C reactive protein (hsCRP) in MS group were significantly higher than non-MS group, while high density lipoprotein-cholesterol (HDL-C) in MS group was significantly lower than non-MS group. The IMT in fat abnormal subgroup, glucose abnormal subgroup, glucose and fat both abnormal subgroup and non-MS group, were (0.86±0.18) mm, (0.90±0.20) mm, (0.89±0.18) mm and (0.84±0.17) mm, respectively (p=0.001). In MS group with abnormal blood glucose, the incidence of IMT and plaque was the highest. Logistic regression analysis showed that males, age, smoking, MS, FBG, LDL-C were the independent risk factors for carotid atherosclerosis. IMT was strongly related with FBG.

Conclusion MS has significant effects on carotid athersclerosis in patients with EH. Glucose may play more important part in carotid athersclerosis than other compositions.

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