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Cardiovascular clinical pharmaceutical research
The study of the relationship between the number of non-campacted segments and left ventricular systolic function in patients with left ventricular non-compaction
  1. Li Yuelin
  1. Department of Uitrasound, Union Hospital, Tongji Medical College, Huazhong University Of Science And Technology, Wuhan, China

Abstract

Objective This study sought to investigate the correlation between the left ventricular systolic function and the number of non-campacted segments in patients with left ventricular non-compaction (LVNC).

Methods 60 patients with the uItrasonic diagnosis of LVNC were enrolled in this study, age of 15 to 87. Left ventricular ejection fraction (LVEF) were measured by biplane Simpson's method with two-dimensional echocardiography. The number of the non-campacted segments were counted, according to 17 segment model of left ventricular. The correlation between the left ventricular systolic function and the number of non-campacted segments and cut-off value of segment number were analysed by ROC curve. According to the cut off by ROC curve, two groups were divided. In group A, patients had the number of the non-compacted segments was less than 6. In group B, patients had the number of the non-compacted segments was and more than 6.

Results (1) There was significant negative correlation between left ventricular ejection fraction and the numbers of non-campacted segments (r=−0.506, p<0.01). (2) By ROC curve, the cut-off value of the number of non-campacted segments was 5.5. 5.5 segments of non-compaction has 76.20% sensitivity and 88.90% specificity respectively for diagnosing left ventricular dysfunction. The area under the ROC curve was 0.839. (3) Compared group A, left ventricular end-diastolic volume, left ventricular end-systolic volume and left ventricular end-diastolic diameter increased significantly in group B (p<0.01). Whereas left ventricular ejection fraction decreased significantly in B group (p<0.01).

Conclusions There was good correlation between left ventricular ejection fraction and the number of non-campacted segments in patients with LVNC. The number of non-campacted segments is an important factor of left ventricular systolic dysfunction.

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