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Cardiovascular clinical pharmaceutical research
Genetic polymorphisms of VKORC1, CYP2C9, CYP4F2 in Bai-, Zang-Chinese
  1. Ceng Wu Tao
  1. First Affiliated Hospital of Zhongshan Medical University, Zhongshan, China

Abstract

This study aims to detect the popular polymorphisms in VKORC1, CYP2C9 and CYP4F2 in Bai-, Zang-Chinese, to start the exploration of better use of warfarin in Chinese minorities.

Methods 370 healthy, unrelated individuals were enrolled, including 131 Han-Chinese, 132 Bai-Chinese? and 107 Zang-Chinese. PCR-based methods (PCR-RFLP) were used to analyse VKORC1 3673G>A, CYP2C9*3, CYP4F2 rs2108622 C>T in Han-, Bai- and Zang-Chinese.

Results The differences among the mutation frequencies of the studied genes in three ethnics were not statistically significant. A-allele in VKORC1 3673G>A was quite common in three studied ethnics. *3-allele in CYP2C9*3 was rare. Approximately one third of each ethnic had the mutant T-allele of CYP4F2 rs108622. However, Bai-Chinese got statistically higher A-allele frequencies of VKORC1 3673G>A than previously studied Han-Chinese did. Also, Zang-Chinese showed significantly lower CYP2C9*3 frequency than combined Han-Chinese, which indicated lower warfarin dose.

Conclusions (1) Attribute to obvious contribution of VKORC1 3673G>A to warfarin dose variation, Bai-Chinese got the potential to benefit more from lower warfarin dose. (2) Due to CYP2C9*3's medium contribution to warfarin dosage variation, moderate adjustment of dosing algorithm or multiple linear regression models is needed for Zang-Chinese in the future.

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