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Cardiovascular clinical pharmaceutical research
Metabolic syndrome and risk of atrial fibrillation in Chinese essential hypertensive patients
  1. Peng Feng,
  2. Lin Jinxiu,
  3. Liu Huilan
  1. The First Affiliated Hospital Of Fujian Medical University, Fujian, China


Purpose: Metabolic syndrome (MS) has been associated with a high prevalence of atrial fibrillation (AF) in a community based population. However, there is little data regarding the association between MS and risk of atrial fibrillation (AF) in essential hypertensive (EH) patients.

Methods This was a retrospective cross-sectional analysis of prospectively collected data in a total of 2782 hospitalised EH patients from 1995 to 2007 in China, which were divided into EH+non-MS group (n=1761) and EH+MS group (n=1021) according to MS criteria. And according to with left ventricular hypertrophy (LVH) or not, EH patients were further divided into four subgroups: non-LVH+non-MS+EH group (n=728), non-LVH+MS+EH group (n=439), LVH+non-MS+EH group (n=1033) and LVH+MS+EH group (n=582). The incidence of AF was compared in such groups.

Results From this database there were 1021 patients with MS, and 289 of these patients were diagnosed with AF. The incidence of AF in patients with EH and MS (EH+MS) group was greater than patients only with EH (EH+non-MS). Left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), and left ventricular mass (LVM)were significantly higher in EH+MS group than those in EH+non-MS group. A greater proportion of AF patients also had MS than the patients without AF. Logistic regression analysis suggested age, hypertension duration, LAD, LVEDD, MS, obesity and the use of statins were independent predictors for AF, but not ventricular hypertrophy (LVH). Obesity was the only MS-related risk factors that was an independent risk factor for AF among all the EH patients in this cohort.

Conclusion Our findings suggest that MS but not LVH was associated with the incidence of AF and may be a risk factor for AF.

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