Background We aimed to evaluate whether serum uric acid (UA) was associated with the complexity of coronary artery disease evaluated by Clinical SYNTAX Score (CSS) score.
Methods The study population consisted of 451 patients (69% men) who underwent coronary angiography for the assessment of CAD. Clinical SYNTAX Score (CSS) calculated by multiplying the SYNTAX Score to a modified ACEF score (age/ejection fraction +1 for each 10 ml the creatinine clearance <60 ml/min per 1.73 m2).
Results All subjects were to be divide into three groups according to CSS tertiles: CSSLOW≤9 (n=117), 10≤CSSMID<26, 27.5 (n=171) and CSSHIGH≥27.5 (n=107). Serum UA levels were found to be higher in patients with the CSSHIGH tertile than lower 2 tertiles. Serum uric acid were seemed significant assocation of the score level in CSS after adjustment for other risk factors (CSSMID OR 0.18, p<0.001; CSSHIGH OR 0.99, p=0.002;).
Conclusions Our study showed that serum UA level was significantly associated with the severity and complexity of coronary artery disease evaluated by Clinical SYNTAX Score (CSS) score.