Objective To investigate the effect of the level of HB-EGF in serum on instant restenosis after CHD stenting.
Methods A total of 36 patients with in-stent restenosis and 44 patients free from restenosis confirmed by radiography were enrolled in this study. The level of HB-EGF in serum were compared between the two groups.
Result The level of HB-EGF in the group of with in-stent restenosis was higher than that in the group of non in-stent restenosis. Logistic regression analysis showed that the level of HB-EGF in serum sensitivity index B=0.112, OR=1.025, 95% CI 0.989 to 1.250 (p<0.05).
Conclusion The results suggested that the level of HB-EGF in serum was positively correlated to in-stent restenosis, the level of HB-EGF in serum can promote endotheliocyte proliferation and reconstruction of blood vessel.