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Association of malignancy with the risk of long term death after acute pulmonary embolism
  1. Wang Yong,
  2. Zhang Hongliang,
  3. Zhao Zhihui,
  4. Luo Qin,
  5. Zhao Qing,
  6. Liu Zhihong
  1. Center for Pulmonary Vascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital, Beijing, China


Objective Malignancy is an independent predictor of acute pulmonary embolism (PE), but its long term value with regards to death after acute PE remains largely undefined. The aim of this study is to assess the association of malignancy with the long term risk of death after acute PE.

Method The patients with acute PE were consecutively enrolled. They were followed up regularly with the primary study end point of all-cause death and PE-related death.

Results A total of 224 consecutive patients with acute PE were enrolled for the study with average age of 60±14 years, in which 126 female patients and 4 patients were accompanied with malignancy. After 31±19 months followed up, there were 15 deaths result from all cause and 7 PE-related deaths. Malignancy was an independent predictor of all-cause death (HR 8.51; 95% CI 1.91 to 37.82; p=0.005) and PE-related death (HR 9.10; 95% CI 1.09 to 75.79; p=0.04).

Conclusions Malignancy increases the risk of long-term death after acute pulmonary embolism.

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