Objective To analyse the relationship between 24 h ABPM rhythm and crPWV, IMT in prehypertensive subjects.
Methods According to the blood pressure level, 286 cases were divided into two groups, namely, normotensive controls 90 cases; prehypertensive participants 196 cases. Meanwhile, prehypertensive subjects were divided into two groups depending on 24 h ABPM, which were 103 and 93 cases in dipper and non-dipper group respectively, 24 h ABPM, crPWV and IMT were tested for all subjects.
Results Twenty four h systolic blood pressure (24 h SBP) was higher in non-dipper group than in dipper group ((126.74±7.38) vs (120.11±8.15) mm Hg, p<0.05). In accordance with systolic blood pressure fall (SBPF), diastolic blood pressure (DBPF), nocturnal systolic blood pressure (nSBP), nocturnal diastolic blood pressure (nDBP), there were significant difference between non-dipper group and dipper group (p<0.01). Brachial-anlde pulse wave velocity (crPWV) ((9.85±1.04) vs (9.02±0.99) m/s, p<0.01) and intima media thickness (IMT)
((0.91±0.15) vs (0.84±0.12) mm, p<0.05) were changed more obviously in non-dipper group than dipper group. Some factors including SBPF, DBPF, daytime systolic blood pressure (dSBP) affected crPWV and IMT was affected by total cholesterol, SBPF, 24 h SBP, dSBP.
Conclusion The abnormal rhythm of 24 h ABPM lead to more serious transformation of vessel wall in prehypertensive subjects, and was more correlated with crPWV and IMT.