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Hypertension
The relationship between 24 h ambulatory blood pressure monitoring rhythm and carotid-radial pulse wave velocity, intima media thickness in prehypertensive subjects
  1. Zhao Yingxin,
  2. Lu Fang Hong,
  3. Wang Shujian,
  4. Liu Zhendong,
  5. Sun Shangwen,
  6. Hu Xiaoliang,
  7. Li Jun,
  8. Kou Xuejun
  1. Shandong Institute of Basic Medical Sciences Research Center of cardiovascular disease, Shandong Academy of Medical Sciences, Shandong, China

Abstract

Objective To analyse the relationship between 24 h ABPM rhythm and crPWV, IMT in prehypertensive subjects.

Methods According to the blood pressure level, 286 cases were divided into two groups, namely, normotensive controls 90 cases; prehypertensive participants 196 cases. Meanwhile, prehypertensive subjects were divided into two groups depending on 24 h ABPM, which were 103 and 93 cases in dipper and non-dipper group respectively, 24 h ABPM, crPWV and IMT were tested for all subjects.

Results Twenty four h systolic blood pressure (24 h SBP) was higher in non-dipper group than in dipper group ((126.74±7.38) vs (120.11±8.15) mm Hg, p<0.05). In accordance with systolic blood pressure fall (SBPF), diastolic blood pressure (DBPF), nocturnal systolic blood pressure (nSBP), nocturnal diastolic blood pressure (nDBP), there were significant difference between non-dipper group and dipper group (p<0.01). Brachial-anlde pulse wave velocity (crPWV) ((9.85±1.04) vs (9.02±0.99) m/s, p<0.01) and intima media thickness (IMT)

((0.91±0.15) vs (0.84±0.12) mm, p<0.05) were changed more obviously in non-dipper group than dipper group. Some factors including SBPF, DBPF, daytime systolic blood pressure (dSBP) affected crPWV and IMT was affected by total cholesterol, SBPF, 24 h SBP, dSBP.

Conclusion The abnormal rhythm of 24 h ABPM lead to more serious transformation of vessel wall in prehypertensive subjects, and was more correlated with crPWV and IMT.

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