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Organic cardiovascular disease (myocarditis, cardiomyopathy, congenital heart disease, rheumatic heart disease,valve)
Transcatheter closure of very large secundum atrial septal defects: long-term follow-up study
  1. Wu Hong,
  2. Liu Jing,
  3. Zhao Xianxian,
  4. Liu Bo,
  5. Wang Yanyan,
  6. Zhen Xing,
  7. Sun Jing,
  8. Pan Jingwei,
  9. Guo Fuzhi,
  10. Li Weiping,
  11. Wang Ersong,
  12. Qin Yongwen
  1. Department of Cardiology, Changhai Hospital


Aims To evaluate the efficacy and safety of transcatheter closure of very large secundum atrial septal defects (ASD) with long-term follow-up results.

Methods and results From June, 2001 to June, 2008, 74 patients diagnosed as secundum atrial septal defect with a diameter more than 30 mm were enrolled in the study. Percutaneous closure of ASDs were attempted by using the Domestic Shanghai ASD-O guided by transthoracic echocardiography (TTE). For the group of the 74 patients, 68 of them are adults. The closure was successful in 71/74 patients (96%). The mean diameter of the device was 38.2±2.73 mm. During the follow-up, complete closure could be achieved in 100% of patients. 7 adverse events (9.9%) were reported. Most adverse events were categorised as minor and there was one major adverse events (1.4%).

Conclusion Transcatheter device closure is an effective management option for patients with very large ASD. Serious complications were rare.

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