Article Text


Heart failure and left ventricular function
LV diastolic function and filling pressure assessment using the time intervals changes on the mitral inflow and mitral annular velocities
  1. Huang Feiqiong,
  2. Tan Rusan
  1. National Heart Centre Singapore


Background The aim of our study was to evaluate left ventricular (LV) function using the time intervals between mitral inflow and mitral annular velocities.

Methods 40 patients (mean age: 42 years) with heart failure and 30 age-matched controls (mean age: 41 years) were enrolled. Patients were classified into two groups according to the ratio of E/E': (1) group 1: E/E' from 8 to 15; (2) group 2: E/E'>15. The measurements were: the time intervals from the R-wave on the ECG to the peak E-wave and the onset of E-wave on the transmitral flow (TMF) (R-pE, R-onset E), to the peak E’-wave and onset of E’-wave on the LV septal wall of TDI (R-pE', R-onset E’); The time intervals from the onset of P-wave on the ECG to the peak A-wave and onset of A-wave on the TMF (P-pA, P-onset A), to the peak A’-wave and onset of A-wave on TDI (P-pA', P-onset A’).

Results The time intervals were shown in table 1. The time intervals of P-pA' and P-onset A’ were significantly decreased in group 1 and group 2 compared to the control group respectively (121.1±13.0, 91.6±20.5 vs 157.2±16.3, p<0.001), (71.1±14.3, 63.2±19.0 vs 49.7±12.3, p<0.001).

Table 1

The time intervals on the mitral flow and TDI in three groups

Conclusion The time intervals of P wave to A wave on TDI changed earlier than on the pulsed Doppler when the LV filling pressure increased, and it may be a useful new method to evaluate the LV diastolic function in patients with heart diseases.

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