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Clinical and research medicine
Heart failure and left ventricular function
Effect of valsartan and carvedilol on TNFα, IL-6 and angiotensin α on geriatric chronic heart failure
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  1. Chen Xianghong,
  2. He Shufen,
  3. He Haiwu
  1. Department of Cardiology, Hainan Provincial Nongken Hospital

Abstract

Objective To observe the effect of Valsartan and carvedilol on TNFα, IL-6 and angiotensin II (Ang II) in geriatric chronic heart failure (CHF).

Methods 95 cases of the aged patients with CHF were randomised into two groups, valsartan group and valsartan combined carvedilol group. Radioactive immunoassays were used to measure the levels of Ang II, TNFα and IL-6 before treatment and three months after treatment.

Results Blood plasma TNFα and IL-6 levels fell down in valsartan group and valsartan combined carvedilol group after treatment (p<0.01). There was no significant difference of Ang II after treatment between the two groups (p>0.05).

Conclusions Cardiac function of CHF was improved significantly after treatment of valsartan or valsartan combined carvedilol. Treatment of valsartan combined carvedilol is better than that of valsartan in decrease of blood plasma TNFα and IL-6 levels and improvement of cardiac function.

https://doi.org/10.1136/heartjnl-2011-300867.661

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