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Biomarkers and laboratory testing for cardiovascular disease>
Relations of NT-proBNP and short-term prognosis of heart failure in patients with acute myocardial infarction
  1. Yang Ming,
  2. Huang Zhenwen
  1. Department of Cardiology, The First Affiliated Hospital, Zhengzhou University, Henan, Zhengzhou, China

Abstract

Objective To investigate the relationship between serial NT-proBNP levels and short-term prognosis of heart failure in AMI patients.

Methods One hundred and ten patients with acute myocardial infarction were divided into two groups: heart failure group and non-heart failure group. The rapid plasma NT-proBNP levels were measured in all patients before treatment and at 24 h, 7 days after treatment. All patients were followed up after admission for 30 days.

Results At admission and at 24 h, 7 days immediately, there was significant difference between two groups. NT-proBNP levels in non-heart failure group showed no significant difference at admission and at 24 h, 7 days after admission (p>0.05), but NT-proBNP levels in heart failure group increased significantly at 24 h, 7 days after admission (p<0.01). UCGs showed that LVEF and LVEDD in no-heart failure group were better than in heart failure group at 7 days after admission. NT-proBNP level was negatively correlated to LVEF (r=–0.393, p<0.01), but positively correlated with LVEDD (r=0.425, p<0.01). NT-proBNP levels at admission and at 24 h, 7 days were markedly correlated to the occurrence of heart failure events (p<0.01).

Conclusion The plasma NT-BNP levels could be a predictor for occurrence of heart failure in AMI patients, and serial NT-BNP measurements are superior to a single BNP value obtained at baseline.

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