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Biomarkers and laboratory testing for cardiovascular disease>
Effects of simvastatin on blood levels of inflammatory cytokines in patients with unstable angina post percutaneous coronary intervention
  1. Tao Chun-Ming,
  2. Chen Jing-Guo,
  3. Shen Tong-Tong,
  4. Zhou Li-Min,
  5. Zhang Jun
  1. Department of Cardiology, Chuzhou Clinical Hospital of Anhui Medical University, The First People Hospital of Chuzhou, Chuzhou, Anhui, China

Abstract

Objective To investigate the effect of simvastatin on blood levels of high-sensitive c-reactive protein (hs-CRP) and interleukin 6 (IL-6) in patients with unstable angina post percutaneous coronary intervention (PCI).

Method Eighty patients who underwent PCI from January 2007 to August 2008 in our hospital were randomised into two groups: control group and simvastatin group (40 mg/day). Serum levels of hs-CRP, and IL-6 were measured before and after one week treatment and at 24 h after PCI.

Results The serum levels of hs-CRP and IL-6 in simvastatin group were distinctly lower than those in control group before (p<0.05) and after the PCI (p<0.05), respectively.

Conclusions The result suggested that PCI could lead to a detectable increase in serum levels of hs-CRP and IL-6 in patients with coronary heart disease; Simvastatin could significantly decrease the serum levels of hs-CRP and IL-6 in patients with coronary heart disease; Simvastatin could also decrease the serum levels of hs-CRP and IL-6 in patients with PCI.

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