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Cardiovascular disease basic research
Association of 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A polymorphism with the elderly ACS
  1. Guoping He,
  2. Jingjiao Hui,
  3. Dandan Shen
  1. Department of Cardiology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, China

Abstract

Objective To investigate the possible association between 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A polymorphism and acute coronary syndrome (ACS) in the elderly (age≥60 years).

Methods A case-control study was conducted in 377 aged patients with ACS (male: 242 cases, female: 135 cases, from 60 to 99 (70.24±6.99) year old) (ACS group) and 337 control subjects (male: 167 cases, female: 170 cases, from 60 to 88 (68.72±6.55) year old) who were free from coronary heart disease (control group). The ALOX5AP SG13S114T/A polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism analysis.

Results (1) Genotype frequencies of ALOX5AP gene SG13S114T/A AA, AT and TT were 13.79%, 50.93% and 35.28% in patients with ACS and 12.76%, 38.58% and 48.66% in control subjects. There was statistical difference of frequencies of AT and TT genotype between ACS group and control group (p<0.05). The T allele frequency was 69.74% in patients with ACS and 61.22% in control subjects and not significantly different between patients with ACS and controls (p>0.05). (2) Subgroup analysis found that as compared with the control group, the AT genotype frequency in male ACS group was significantly higher (40.72% vs 52.48%, p<0.05) and the TT genotype frequency in female ACS group was significantly lower (61.76% vs 37.04%, p<0.05). Subgroup multivariate logistic regression analysis showed AT and TT genotype and T allele with male ACS as well (p were 0.014, 0.005 and 0.020, respectively).

Conclusion The AT and TT genotype and The T allele of ALOX5AP gene SG13S114T/A polymorphism may be associated with the susceptibility to ACS in the elderly, especially the aged male, in the Chinese Han population of Sunan region.

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