Objective To investigate increased ambulatory arterial stiffness index correlated with plasma level and expression of monocyte chemoattractant protein-1.

Methods 108 subjects with prehypertension and 101 optimism mormotensive subjects were eligible to be enrolled. Noninvasive ambulatory blood pressure monitoring was performed using automatic devices (TM-2421 and TM-2430; A&D Co Inc., Tokyo, Japan) and ambulatory arterial stiffness index was calculated in all participants. monocyte chemoattractant protein-1 expression was conducted by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR).

Results Ambulatory arterial stiffness index was 0.48±0.10 % in prehypertensives, higher than that in optimism normotensives (t value=10.689, p-1 in prehypertensives.