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Cardiovascular disease basic research
Increased ambulatory arterial stiffness index correlated with monocyte chemoattractant protein-1 in prehypertensives
  1. Liu Zhendong,
  2. Lu Fanghong,
  3. Zhao Yingxin,
  4. Wang Shujian,
  5. Sun Shangwen,
  6. Pan Hui
  1. Cardio-cerebrovascular Control And Research Center, Shandong Academy Of Medical Sciences, Shandong, China

Abstract

Objective To investigate increased ambulatory arterial stiffness index correlated with plasma level and expression of monocyte chemoattractant protein-1.

Methods 108 subjects with prehypertension and 101 optimism mormotensive subjects were eligible to be enrolled. Noninvasive ambulatory blood pressure monitoring was performed using automatic devices (TM-2421 and TM-2430; A&D Co Inc., Tokyo, Japan) and ambulatory arterial stiffness index was calculated in all participants. monocyte chemoattractant protein-1 expression was conducted by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR).

Results Ambulatory arterial stiffness index was 0.48±0.10 % in prehypertensives, higher than that in optimism normotensives (t value=10.689, p-1 in prehypertensives.

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