Objective This experiment aimed to observe the effect of CSWT on matrix metalloproteinase and relative inhibitive factors, and explore the potential biology mechanism that inhibit ventricular remodeling after acute myocardial infarction in pigs.
Methods A total of 30 domestic miniature pigs were involved in this study. The methods of grouping and treatment were same with those in part experiment. At 30 days, the expression levels of mRNA of MMP1 and TIMP1 were measured and evaluated.
Results At 30 days, compared to pseudo-CSWT group, the mRNA expression of TIMP1 was up-regulated significantly in CSWT group (32.87±9.13 vs 20.17±6.31, p<0.001), while the expression of MMP1 was significantly decreased 9.38±1.85 vs 13.52±3.14, p<0.001; Which is consistent with the results of increased VEGF expression and higher collateral vessel Rentrop score in this group.
Conclusions CSWT can induce angiogenesis, up-regulate the expression of angiogenic factor, depress promote factor of ventricular remodeling, promote micro-vascular circulation reconstruction of ischemia myocardial and inhibit ventricular remodeling. It may be the potential mechanism that cardiac shock wave therapy regulates metabolism balance of myocardial extra-cellular matrix and improve ventricular remodeling.