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The Authors' reply Recently, we reported a case-control study in which we found that both patients with premature coronary artery disease (CAD) and their ‘healthy’ asymptomatic first degree relatives had increased arterial stiffness compared with controls.1 Noteworthy, these patients and their first degree relatives had at least two prematurely affected relatives within their family. With interest we read the comment by Zaman2 who disputes that a family history of premature CAD is an important risk factor on a population base, for which he refers to the INTERHEART study.3 However, we have several arguments to oppose his statement.
We agree that the INTERHEART study shows that a combination of nine risk …
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