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Heart 98:891 doi:10.1136/heartjnl-2012-301945
  • PostScript
  • Correspondence

The Authors' reply

  1. Sara-Joan Pinto-Sietsma1,2
  1. 1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
  2. 2Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Dr Sara-Joan Pinto-Sietsma, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Postbus 22660, 1100 DD Amsterdam, The Netherlands; s.j.pinto{at}amc.nl

The Authors' reply Recently, we reported a case-control study in which we found that both patients with premature coronary artery disease (CAD) and their ‘healthy’ asymptomatic first degree relatives had increased arterial stiffness compared with controls.1 Noteworthy, these patients and their first degree relatives had at least two prematurely affected relatives within their family. With interest we read the comment by Zaman2 who disputes that a family history of premature CAD is an important risk factor on a population base, for which he refers to the INTERHEART study.3 However, we have several arguments to oppose his statement.

We agree that the INTERHEART study shows that a combination of nine risk …