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Systemic to pulmonary collateral blood flow influences early outcomes following the total cavopulmonary connection
  1. Tobias Odenwald1,
  2. Michael A Quail1,
  3. Alessandro Giardini2,
  4. Sachin Khambadkone2,
  5. Marina Hughes1,
  6. Oliver Tann1,
  7. Tain-Yen Hsia2,
  8. Vivek Muthurangu1,
  9. Andrew M Taylor1
  1. 1Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science & Great Ormond Street Hospital for Children, London, UK
  2. 2Cardiorespiratory Unit, Great Ormond Street Hospital for Children, London, UK
  1. Correspondence to Dr Michael A Quail, Cardiorespiratory Unit, Great Ormond Street Hospital for Children, Level 6 Old Nurses Home, Great Ormond Street, London WC1N 3JH, UK; m.quail{at}ucl.ac.uk

Abstract

Background Systemic to pulmonary collaterals (SPCs) represent an additional and unpredictable source of pulmonary blood flow in patients with single ventricle physiology following bidirectional superior cavopulmonary connection (BCPC). Understanding their influence on patient outcomes has been hampered by uncertainty about the optimal method of quantifying SPC flow.

Objective To quantify SPC flow by cardiac magnetic resonance (CMR) prior to total cavopulmonary connection (TCPC) in order to identify preoperative risk factors and determine influence on postoperative outcomes.

Design Single centre prospective cohort study.

Setting Tertiary referral centre.

Patients 65 patients with single ventricle physiology undergoing CMR for preoperative assessment of TCPC completion underwent quantification of SPC flow. Clinical outcomes of 41 patients in whom TCPC was completed were obtained.

Main outcome measures Early post-TCPC clinical outcomes associated with SPC flow were assessed, including postoperative chest drainage volume, postoperative chest drainage duration and length of intensive care and hospital stays. Additionally preoperative covariates associated with SPC flow were assessed including age at BCPC and CMR, SpO2 at BCPC and CMR, ventricle type, pulmonary artery (PA) cross-sectional area and PA pulsatility. Different methods of CMR SPC flow quantification were compared.

Results Higher SPC flow was associated with increased postoperative chest drain volume (r=0.51, p=0.001), chest drain duration (r=0.43, p=0.005), and intensive care unit (r=0.32, p=0.04) and log-transformed hospital stays (r=0.31, p=0.048). The effect of SPC flow on outcome was independent of fenestration, ventricle type and function. Preoperative covariates associated with SPC flow included age at BCPC (β=−0.34, p=0.008), SpO2 at time of CMR (β=0.34, p=0.004) and branch PA cross-sectional area (β=−0.26, p=0.036), model R2=0.34. Moreover, patients with pulsatile pulmonary blood flow had lower SPC flow than those without (0.8 vs 1.3 l/min/m2 p=0.012). SPC flow calculated by the difference between pulmonary venous return and pulmonary artery flow (l/min/m2) showed greatest association with preoperative covariates and strongest correlation with postoperative outcomes compared with other methods of quantification.

Conclusions CMR can provide an effective measurement of SPC flow prior to TCPC. Young age at BCPC, high preoperative oxygen saturation and smaller PAs are associated with increased SPC flow, which may promote increased postoperative pleural drainage and lengthen recovery.

  • Single ventricle
  • systemic pulmonary collaterals
  • TCPC
  • BCPC
  • MRI
  • congenital heart disease
  • fallots tetralogy
  • paediatric cardiology
  • paediatric arrythmias
  • paediatric cardiac function
  • paediatric surgery
  • transposition of the great arteries
  • paediatric ultrasound
  • congenital-adult
  • CT scanning
  • surgery-paediatric
  • haemodynamics
  • thoracic imaging
  • cardiac anatomy
  • cardiac function

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Footnotes

  • T Odenwald and MA Quail contributed equally to this paper.

  • Funding MAQ is funded by a British Heart Foundation Clinical Research Training Fellowship. TO is funded by a Marie Curie fellowship. VM is funded by the British Heart Foundation as a BHF Intermediate Fellow. AG, SK and T-YH are funded by the Fondation Leducq. AMT is funded by the National Institute of Health Research as an NIHR Senior Research Fellow and by the Fondation Leducq.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Institute of Child Health Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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