(A) Typical histopathology in an endomyocardial biopsy of a patient with hypertrophic cardiomyopathy (HCM). (a) A general view, haematoxylin and eosin (H&E) ×200; (b, c) moderate fibre disarray, interstitial fibrosis (asterisk), moderate myocyte size heterogeneity and hypertrophy and scattered mononuclear inflammatory cells (arrows), H&E ×400, ×630. (B) Mild histopathological findings in a patient with HCM. (a) A general view, H&E ×200; (b, c) mild fibre disarray, fibrosis (asterisk), myocyte hypertrophy and occasional mononuclear inflammatory cells (arrow), H&E ×400, ×630. (C) Severe HCM. (a) A general view: Weigert van Gieson staining highlights marked fibrosis (red, shown by asterisk), ×200; (b) multiple mononuclear inflammatory cells (arrow); (C) showing CD3 positivity in immunohistochemistry (staining in brown, arrow). Original magnification ×400. The patient had severe symptoms, marked left ventricular hypertrophy and inducible ventricular arrhythmia in ventricular stimulation. An intracardiac defibrillator was subsequently implanted.
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