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Utility of self-reported diagnosis and electrocardiogram Q-waves for estimating myocardial infarction prevalence: an international comparison study
  1. Andrew Moran1,
  2. Albert Shen1,
  3. Daniel Turner-Lloveras1,
  4. Aayla Khan2,
  5. Els Clays3,
  6. Walter Palmas1,
  7. Dirk De Bacquer3
  1. 1Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, USA
  2. 2Mailman School of Public Health, Columbia University, New York, U.S.A
  3. 3Department of Public Health, Ghent University, Ghent, Belgium
  1. Correspondence to Dr Andrew Moran, Division of General Medicine, Columbia University, Presbyterian Hospital room PH 9 East 105, 630 West 168th Street, New York, NY 10032, USA; aem35{at}columbia.edu

Abstract

Objective Self-report of physician diagnosis and ECG ‘Q’ waves are common survey measures of prior myocardial infarction (MI) prevalence. We sought to assess relative prevalence of self-reported prior MI and ECG Q-waves (ECG-MI) in populations and population subgroups with varying MI prevalence.

Design A secondary analysis of seven population-based cross-sectional surveys of prevalent MI selected from a systematic review of ischaemic heart disease epidemiology.

Setting Men and women aged 45–74 years in population-based Belgian surveys (1978–-1998, n=29 419) and US National Health and Nutrition Examination Surveys (1976–1994, n=11 107). Comparison of the US and Belgian surveys with surveys in seven other nations (United Kingdom, Russia, Lithuania, Belarus, India, Turkey and Ghana).

Main outcome measures Prevalence of prior MI measured by self-report or resting ECG Q-waves (ECG-MI; Minnesota ECG codes 1.1 and 1.2).

Results Self-reported prior MI prevalence was 1.5–2.6 times higher than ECG-MI in Belgian and US men aged 45–74 years and women 55–74 years. ECG-MI was more prevalent than self-reported MI in women <55 years old, and self-reported MI relatively low in US African–American men compared with US Caucasian men. In the overall nine-nation comparison, there was no consistent relationship between self-reported MI and ECG-MI. ECG-MI was higher relative to self-report in nations with lower prevalence of ischaemic heart disease.

Conclusions Self-reported MI and ECG-MI prevalence may only be reliable in higher ischaemic heart disease incidence groups. Self-report and ECG-MI have limited accuracy, and ECG Q-waves likely capture fewer prior MIs in the 21st century. The limitations of current survey prevalence measures of MI should be taken into account when measuring the burden of ischaemic heart disease in populations.

  • Myocardial infarction
  • prevalence
  • self-report
  • electrocardiography
  • international comparison

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Footnotes

  • Funding Supported by a Career Development Award (K08 HL089675) from the National Heart, Lung, and Blood Institute of the US National Institutes of Health to Dr Moran. Dr Moran's and Dr Khan's work on the GBD Study systematic review of ischaemic heart disease epidemiology was supported by a grant from the Bill and Melinda Gates Foundation.

  • Competing interests None.

  • Ethics approval This study was an analysis of pre-existing data. All Belgian study data were collected in the past after obtaining informed consent and local ethics board approvals. US NHANES data are publicly available. No individual-level identifiers were used at any stage of the analysis.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Pooled data from the Belgian surveys are available upon request from DD. Data from the US NHANES are publicly available. All published papers included from the systematic review are publicly available.

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