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Heart 98:1732-1737 doi:10.1136/heartjnl-2012-302376
  • Original articles
    • Acute coronary syndromes

Prevalence, predictors and clinical impact of unique and multiple chronic total occlusion in non-infarct-related artery in patients presenting with ST-elevation myocardial infarction

  1. Olivier F Bertrand
  1. Quebec Heart-Lung Institute, Quebec, Canada
  1. Correspondence to Dr Olivier F Bertrand, Interventional Cardiology, Quebec Heart-Lung Institute, 2725, chemin Ste Foy, Quebec City, Canada; olivier.bertrand{at}crhl.ulaval.ca
  1. Contributors All authors have participated in data collection. YB and OFB generated the idea and wrote the protocol. YB collected the data pertaining to the study. YB, UD, OC, JM, TA and OB analysed the data. YB wrote the first draft. All coauthors reviewed the successive drafts and approved the final version submitted. YB and OB are responsible for the overall content of the article.

  • Accepted 14 August 2012
  • Published Online First 26 September 2012

Abstract

Objectives To investigate the predictors and impact on long-term survival of one chronic total occlusion (CTO) or multiple CTOs in patients presenting with ST-elevation myocardial infarction (STEMI).

Design Single-centre retrospective observational study.

Setting University-based tertiary referral centre.

Patients Between 2006 and 2011, a total of 2020 consecutive patients referred with STEMI were categorised into single vessel disease, multivessel disease (MVD) without CTO, with one CTO or with multiple CTOs.

Intervention Primary percutaneous coronary intervention.

Main outcome measure The primary end-point was the 1-year mortality.

Results The prevalence of single vessel disease, MVD without CTO, with one CTO or with multiple CTOs was 70%, 22%, 7.2% and 0.8%, respectively. Independent clinical predictors for the presence of CTO were cardiogenic shock (OR 5.05; 95% CI 3.29 to 7.64), prior myocardial infarction (OR 2.06; 95% CI 1.35 to 3.09), age >65 years (OR 1.94; 95% CI 1.40 to 2.71) and history of angina (OR 1.94; 95% CI 1.29 to 2.87). Mortality was worse in patients with multiple CTOs (76.5%) compared with those with one CTO (28.1%) or without CTO (7.3%) (p<0.0001). After adjustment for left ventricular ejection fraction and renal function, MVD was an independent predictor for 1-year mortality (HR: 1.81; 95% CI 1.18 to 2.77, p=0.007), but CTO was not (HR: 1.07; 95% CI 0.66 to 1.73, p=0.78).

Conclusions Simple clinical factors are associated with the presence of CTO in non-infarct-related artery in patients presenting with STEMI. In these patients, long-term survival was independently associated with MVD, left ventricular ejection fraction and renal function, but not with CTO per se.

Footnotes

  • Funding Y Bataille received a fellowship grant from the Centre Hospitalier Régional ‘Citadelle’, Liège, Belgium, and a research fellowship grant from the ‘Fonds Léon Fredericq’ at University of Liège, Belgium.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was obtained from Laval Hospital Ethics Review Board, Quebec City, Canada, Quebec Heart-Lung Institute IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.