1. Re: Quantitative myocardial perfusion analysis using multi-row detector CT in acute myocardial infarction

    Dear Editors:

    We are writing in regards to the paper entitled "Quantitative myocardial perfusion analysis using multi-row detector CT in acute myocardial infarction" that is recently published in the April 2012 issue of Heart. We would like to congratulate the authors for a very interesting study that has used all the advanced techniques available in the GE Healthcare CT Perfusion research version software. We are the core laboratory that develop and validate the techniques in that version of the software and are very pleased that they are being used successfully in their work. Instead of references #13-16 in their paper, the correct references that detail our work implemented in the software are as follows:

    1. So A et al. Beam hardening correction in CT myocardial perfusion measurement. Phys Med Biol 2009;54(10):3031-3050

    2. So A et al. Quantitative myocardial perfusion measurement using CT Perfusion: a validation study in a porcine model of reperfused acute myocardial infarction. Int J Cardiovasc Imaging. Epub 2011 Jul 29

    3. So A et al. Non-invasive assessment of functionally relevant coronary artery stenoses with quantitative CT perfusion: preliminary clinical experiences. Eur Radiol 2012;22(10):39-50 Epub 2011 Sep 21

    In particular, the beam hardening correction method in the CT Perfusion research version software is based on our work previously published in 2009 (see #1 above) rather than the work of Kitagawa et al as referenced in the paper.

    We hope this clarification would prevent confusion in the mind of readers who read the paper and are stimulated to pursue quantitative myocardial perfusion research.

    Best regards,

    Aaron So, PhD, Associated Scientist, Lawson Health Research Institute, London, Ontario, Canada

    Ting-Yim Lee, PhD, FCCPM, CIHR-GE Healthcare Chair in Functional Imaging; Director, PET/CT Research, Lawson Health Research Institute; Scientist, Robarts Research Institute; Professor, Medical Biophysics, Oncology, Medical Imaging, Western University, London, Ontario, Canada

    Conflict of Interest:

    T.-Y. Lee has a CT Perfusion software licensing agreement with GE Healthcare, and receives research grant support from GE Healthcare, Astra Zeneca and Celgene. A. So has no disclosure.

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