Introduction A gold standard test for arrhythmogenic right ventricular cardiomyopathy (ARVC) does not exist and diagnosis relies on meeting Task Force criteria. Sudden death remains the first clinical presentation in up to 23% of subjects. In ischaemic heart disease prolongation of the ventricular ectopic QS interval (VEQSI) has been shown to correlate with presence and severity of myocardial disease. We evaluated the significance of VEQSI in patients with ARVC.
Methods We selected 3 cohorts for 12 lead 24-h Holter monitoring: 51 normal controls (41.7±14.8 years; 55% male); 27 patients with definite ARVC by Task Force criteria (46.4±13.1 years; 70% male); 10 patients with borderline ARVC and a confirmed pathogenic mutation and/or definitely affected first degree relative (34.6±13.0 years; 50% male). All ventricular ectopics (VE) were reviewed and VEQSI was measured for each VE morphology. The longest VE duration was recorded as VEQSI max.
Results VEQSI max was significantly longer in definite ARVC compared with borderline ARVC and normal controls (208.8±18.6 ms, 183.7±12.9 ms and 155.0±14.4 ms respectively; p<0.001). VEQSI max was also significantly longer in borderline ARVC compared with normal controls (p=0.002). When the upper normal limit for VEQSI max was defined as 170 ms there was 97% sensitivity and 93% specificity for diagnosis of ARVC, including 9/10 correct diagnoses in the borderline ARVC group.
- Ventricular ectopic QS interval (VEQSI)
- arrhythmogenic right ventricular cardiomyopathy (ARVC)
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.