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GW23-e2279
PI3K/AKT/ENOS/HSP70 MEDIATES ATORVASTATIN POST-CONDITIONING AGAINST MYOCARDIAL ISCHAEMIA-REPERFUSION INJURY IN TYPE 2 DIABETIC RATS
  1. Cheng Zhen-dong,
  2. Chen Liang-long
  1. Cardiology Department, Union Hospital, Fujian Medical University, Fuzhou

    Abstract

    Objectives group

    Methods group

    Results Compared with I/R group, different dosage (0.1, 0.5, 1.0 or 2.0 mg/kg) of atorvastatin intervention significantly decreased IS (p<0.01, each dosage), cTnT (p<0.01, each dosage) and Flameng score (p<0.05, each dosage), and increased myocardial expression of phosphorylated AKt (p<0.05, each dosage), phosphorylated eNOS (p<0.05, each dosage) and HSP70 (p<0.05, each dosage), with a dose-dependent manner. As compared to I/R group, LY294002 intervention (PI3KI group, combined intervention of atorvastatin and LY294002) abolished atorvastatin-afforded cardio protection, with no significant differences in IS (p>0.05), cTnT (p>0.05), Flameng score (p>0.05) as well as myocardial expression of phosphorylated AKt (p>0.05), phosphorylated eNOS (p>0.05) and HSP70 (p>0.05) between groups.

    Conclusions Our data suggests that activation of the upstream PI3K-Akt-eNOS pathway and up regulation of the downstream protein HSP70 contribute to atorvastatin post conditioning cardio-protection in type 2 diabetic rat.

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