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GW23-e1874
SIMVASTATIN PREVENT ATHEROSCLEROSIS DEVELOPMENT THROUGH INHIBITING PROTEIN EXPRESSION OF ADHESION MOLECULES
  1. Li xiaoyan,
  2. Lu ying,
  3. Zhang ping,
  4. Qu caihong
  1. The Third Affiliated Hospital of Sun Yat-sen University

    Abstract

    Objectives To explore the effects of simavastatin on protein expressions of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and endothelial leukocyte adhesion molecule 1 (E-selectin) of cholesterol diet rabbits and the underlying mechanisms of the beneficial effects of simvastatin on atherosclerosis (AS).

    Methods Twenty-four male rabbits were randomly divided into three groups: normal diet groups, cholesterol diet groups and the simvastatin groups which received both cholesterol diet and simastatin 5 mg/kg/d intragastrically. ELISA was used to detect plasma protein levels of ICAM-1, VCAM-1 and E-selectin of rabbits at 0, 8 and 16 weeks, respectively. After 16 weeks, rabbits were executed and the artery wall was harvested for the pathologic and morphologic observations. Western blot and RT-PCR were used to determine ICAM-1, VCAM-1 and E-selectin level of rabbits artery wall.

    Results Compared with normal diet groups, the expression of ICAM-1, VCAM-1 and E-selectin in cholesterol diet groups plasma and artery wall was obviously increased both in protein and mRNA level.(n=6; p<0.01). However, simavastatin could inhibit the formation of atherosclerotic plaques obviously; suppress plasma and artery wall protein expression and mRNA level of ICAM-1, VCAM-1 and E-selectin (n=6; p<0.01).

    Conclusions Simvastatin could ameliorates atherosclerosis (AS) through inhibiting expression level of plasma and artery wall adhesion molecule.

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